Structure of PDB 6oz8 Chain L

Receptor sequence

>6oz8L (length=92) Species: 83332 (Mycobacterium tuberculosis H37Rv)

cVTIDADLMDAADLLEGEQVTIVDIDNGARLVTYAITGERGSGVIGINGA
AAHLVHPGDLVILIAYATMDDARARTYQPRIVFVDAYNKPID

3D structure

• PDB: 6oz8 The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD.
• Chain: L
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.11: aspartate 1-decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	L	D37 L39 G41 E42 Q43 Y58 A91 T92	D13 L15 G17 E18 Q19 Y34 A67 T68
BS02	peptide	L	A36 D37 L38 E42 I49 I69 I71 N72 G73 H77 G82 D83 L84 V85 I86 L87 I88 A89 Y90 A91 T92 M93 D95 A98 Y101 P103 R104 I105 V106 F107 V108 N112	A12 D13 L14 E18 I25 I45 I47 N48 G49 H53 G58 D59 L60 V61 I62 L63 I64 A65 Y66 A67 T68 M69 D71 A74 Y77 P79 R80 I81 V82 F83 V84 N88

Gene Ontology

Molecular Function

• GO:0004068 aspartate 1-decarboxylase activity

Biological Process

• GO:0006523 alanine biosynthetic process

External links

• PDB: RCSB:6oz8, PDBe:6oz8, PDBj:6oz8
• PDBsum: 6oz8
• PubMed: 31953389
• UniProt: P9WIL3|PAND_MYCTU Aspartate 1-decarboxylase (Gene Name=panD)