Structure of PDB 6mwn Chain L

Receptor sequence

>6mwnL (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]

DIQMTQSPSSLSASVGDRVTITCRASQSVYYSVAWYQQKPGKAPKLLIYS
ASYLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYRRRPITFGQ
GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV
DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGE

3D structure

PDB

6mwn A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites.

Chain

Resolution

2.838 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	Q28 S29 Y31 R67 G69 R93 R94	Q27 S28 Y30 R66 G68 R92 R93	PDBbind-CN: Kd=44nM
BS02	rna	L	S57 G58 P60 S61 K170	S56 G57 P59 S60 K169	PDBbind-CN: Kd=44nM

External links

PDB	RCSB:6mwn, PDBe:6mwn, PDBj:6mwn
PDBsum	6mwn
PubMed	31399592

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