Structure of PDB 6fwh Chain L

Receptor sequence
>6fwhL (length=195) Species: 5755 (Acanthamoeba castellanii) [Search protein sequence]
KREAQVARETGETKIEVRLSLDGTGVSDVKTGIGFLDHMLSALAKHGRFD
LYLRCAGDLHVDDHHTSEDCAIVLGQAFRQAIGERKGIKRYGSAYAPLDE
SLARAVVDISSRPFAVIDLKLKREKIGELSCEMIPHVLHSFATSANLTLH
VEVLYGANDHHKAESAFKATALALREAVTKDGPADAVPSTKGVLE
3D structure
PDB6fwh Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials.
ChainL
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.19: imidazoleglycerol-phosphate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5LD L R92 R114 S191 K193 R90 R112 S189 K191
BS02 5LD L E14 H66 H67 E70 E12 H64 H65 E68
BS03 MN L H66 E70 H138 H64 E68 H136
BS04 MN L H40 H162 E166 H38 H160 E164
BS05 5LD L H40 H162 H163 E166 H38 H160 H161 E164
BS06 MG L Q7 Q82 Q5 Q80
Gene Ontology
Molecular Function
GO:0004424 imidazoleglycerol-phosphate dehydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0000105 L-histidine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6fwh, PDBe:6fwh, PDBj:6fwh
PDBsum6fwh
PubMed29969448
UniProtL8H477

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