Structure of PDB 6fec Chain L

Receptor sequence

>6fecL (length=137) Species: 9606 (Homo sapiens) [Search protein sequence]

PEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKR
AGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDN
KLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRR

3D structure

PDB

6fec Structure of a human cap-dependent 48S translation pre-initiation complex.

Chain

Resolution

6.3 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	R23 R24 K25 F28 K34 G35 V36 G37 R38 R39 Y40 T53 R55 W82 F83 L84 N85 R86 Q87 K88 V90 L103 L107 D110 H120 R121 L129 R130 V131 R132 G133 Q134 H135 T136 K137 T138 T139 G140 R141 R142	R18 R19 K20 F23 K29 G30 V31 G32 R33 R34 Y35 T48 R50 W77 F78 L79 N80 R81 Q82 K83 V85 L98 L102 D105 H115 R116 L124 R125 V126 R127 G128 Q129 H130 T131 K132 T133 T134 G135 R136 R137

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6fec, PDBe:6fec, PDBj:6fec
PDBsum	6fec
PubMed	29401259
UniProt	P62269\|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)