Structure of PDB 6e88 Chain L

Receptor sequence
>6e88L (length=434) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
MREVISIHVGQAGVQIGNACWELYCLEHGIQPDGTMPTQSTNEGESFTTF
FSDTGSGRYVPRSIFVDLEPTVVDEIRTGTYKKLFHPEQMITGKEDAANN
YARGHYTVGKELIDTVLDRIRRLADNCSGLQGFFVFHSFGGGTGSGFTSL
LMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAF
MVDNEAIYDICRRNLDVERPSYTNLNRIISQVVSSITASLRFDGALNVDL
NEFQTNLVPYPRIHFPLAAYTPLISAEKAYHEALSVSDITNSCFEPANQM
VKCDPRHGKYMAVCLLYRGDVVPKDVNTAIAAIKTKRTIQFVDWCPTGFK
VGINYQPPTVVPGGDLAKVPRAVCMLSNTTAIAEAWSRLDYKFDLMYAKR
AFVHWYVGEGMEEGEFTEAREDLAALEKDYEEVG
3D structure
PDB6e88 The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth.
ChainL
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP L Q11 A12 N99 S138 G141 G142 T143 E181 Y222 Q11 A12 N99 S138 G141 G142 T143 E181 Y222
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0008104 protein localization
GO:0009792 embryo development ending in birth or egg hatching
GO:0032465 regulation of cytokinesis
GO:0051642 centrosome localization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e88, PDBe:6e88, PDBj:6e88
PDBsum6e88
PubMed30245157
UniProtP34690|TBA2_CAEEL Tubulin alpha-2 chain (Gene Name=tba-2)

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