Structure of PDB 6c23 Chain L

Receptor sequence
>6c23L (length=362) Species: 9606 (Homo sapiens) [Search protein sequence]
YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQ
GEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT
MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF
GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD
YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV
CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL
GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC
DDASIWRWDRLR
3D structure
PDB6c23 Structures of human PRC2 with its cofactors AEBP2 and JARID2.
ChainL
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide L F97 N307 Y308 C324 I363 W364 Y365 R414 F18 N228 Y229 C245 I284 W285 Y286 R335
Gene Ontology
Molecular Function
GO:0001222 transcription corepressor binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0031491 nucleosome binding
GO:0042802 identical protein binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0021510 spinal cord development
GO:0031507 heterochromatin formation
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0035098 ESC/E(Z) complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c23, PDBe:6c23, PDBj:6c23
PDBsum6c23
PubMed29348366
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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