Structure of PDB 6bo7 Chain L

Receptor sequence
>6bo7L (length=216) Species: 5855 (Plasmodium vivax) [Search protein sequence]
KIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLK
NRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTES
PKHLYVEHYVRVIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKK
FEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDL
DHLCLVNDEGIKKFRT
3D structure
PDB6bo7 Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ChainL
Resolution2.856 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E144 D145 D148 F197 R210
Catalytic site (residue number reindexed from 1) E132 D133 D136 F185 R198
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG L E144 D145 E132 D133
BS02 MG L S97 T99 E100 S96 T98 E99
BS03 YPG L K77 G78 R112 I146 D148 T149 G150 T152 K176 F197 V198 D204 R210 K76 G77 R111 I134 D136 T137 G138 T140 K164 F185 V186 D192 R198
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bo7, PDBe:6bo7, PDBj:6bo7
PDBsum6bo7
PubMed29161011
UniProtA5K7E9

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