Structure of PDB 6a5z Chain L

Receptor sequence
>6a5zL (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
MPVERILEAELAVEDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQV
ILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDR
VLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYA
SLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPID
TFLMEMLE
3D structure
PDB6a5z Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
ChainL
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide L V280 K284 V298 R302 T449 F450 E453 V32 K36 V50 R54 T201 F202 E205
BS02 9CR L I268 A271 A272 F313 R316 L326 A327 I345 C432 I20 A23 A24 F65 R68 L78 A79 I97 C184 BindingDB: EC50=100nM,Ki=583nM,IC50=32nM,Kd=240nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:6a5z, PDBe:6a5z, PDBj:6a5z
PDBsum6a5z
PubMed30275017
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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