Structure of PDB 5o9z Chain L

Receptor sequence
>5o9zL (length=459) Species: 9606 (Homo sapiens) [Search protein sequence]
IESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSG
HWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMI
MLKQTQPERYIHLENLLARSYFDPREAYPDGSKEKRRAAIAQALAGEVSQ
LSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKY
QAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFER
AHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNE
ATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVI
LLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRG
EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSE
DGLLKLWKP
3D structure
PDB5o9z Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
ChainL
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide L K247 I248 K193 I194
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5o9z, PDBe:5o9z, PDBj:5o9z
PDBsum5o9z
PubMed28781166
UniProtQ2TAY7|SMU1_HUMAN WD40 repeat-containing protein SMU1 (Gene Name=SMU1)

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