Structure of PDB 5nxc Chain L

Receptor sequence
>5nxcL (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
SMPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEET
QRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKS
MDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVA
DFGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMD
FGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLR
MHLAGHLPLGPQLEQLDRGFWETY
3D structure
PDB5nxc LIM Domain Kinase (LIMK1) In Complex With PF-00477736
ChainL
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N465 D478
Catalytic site (residue number reindexed from 1) N138 D151
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9DB L L345 G346 K347 G351 Q352 V366 K368 I416 G419 L467 D478 L18 G19 K20 G24 Q25 V39 K41 I89 G92 L140 D151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5nxc, PDBe:5nxc, PDBj:5nxc
PDBsum5nxc
PubMed
UniProtP53667|LIMK1_HUMAN LIM domain kinase 1 (Gene Name=LIMK1)

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