Structure of PDB 5mpa Chain L

Receptor sequence
>5mpaL (length=388) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
EQEAHNKALNQFKRKLLEHRRYDDQLKQRRQNIRDLEKLYDKTENDIKAL
QSIGQLIGEVMKELSEEKYIVKASSGPRYIVGVRNSVDRSKLKKGVRVTL
DITTLTIMRILPRETDPLVYNMTSFEQGEITFDGIGGLTEQIRELREVIE
LPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPA
SGIVDKYIGESARIIREMFAYAKEHEPCIIFMDEVDAIGGRRFSEGTSAD
REIQRTLMELLTQMDGFDNLGQTKIIMATNRPDTLDPALLRPGRLDRKVE
IPLPNEAGRLEIFKIHTAKVKKTGEFDFEAAVKMSDGFNGADIRNCATEA
GFFAIRDDRDHINPDDLMKAVRKVAEVKKLEGTIEYQK
3D structure
PDB5mpa Structural insights into the functional cycle of the ATPase module of the 26S proteasome.
ChainL
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP L I183 G225 T226 G227 T229 I360 H364 G388 A389 I135 G177 T178 G179 T181 I312 H316 G340 A341
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0036402 proteasome-activating activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0010604 positive regulation of macromolecule metabolic process
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0036503 ERAD pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0031597 cytosolic proteasome complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:5mpa, PDBe:5mpa, PDBj:5mpa
PDBsum5mpa
PubMed28115689
UniProtP53549|PRS10_YEAST 26S proteasome subunit RPT4 (Gene Name=RPT4)

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