Structure of PDB 5dst Chain L

Receptor sequence
>5dstL (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
SYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMF
AAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEK
VDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIED
RQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEV
DIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAP
DAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDF
KGQLCETSVSNDYKMR
3D structure
PDB5dst Novel helical assembly in arginine methyltransferase 8
ChainL
Resolution2.963 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D92 E185 E194 H334
Catalytic site (residue number reindexed from 1) D14 E107 E116 H256
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH L Y80 M89 R95 G119 S120 G121 I124 L125 E141 C142 V169 E170 M196 T199 Y2 M11 R17 G41 S42 G43 I46 L47 E63 C64 V91 E92 M118 T121
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5dst, PDBe:5dst, PDBj:5dst
PDBsum5dst
PubMed26876602
UniProtQ9NR22|ANM8_HUMAN Protein arginine N-methyltransferase 8 (Gene Name=PRMT8)

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