Structure of PDB 4z73 Chain L

Receptor sequence
>4z73L (length=160) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
AMQFDVTIEIPKGQRNKYEVDHETGRVRLDRYLYTPMAYPTDYGFIEDTL
GDDGDPLDALVLLPQPVFPGVLVAARPVGMFRMVDEHGGDDKVLCVPAGD
PRWDHVQDIGDVPAFELDAIKHFFVHYKDLEPGKFVKAADWVDRAEAEAE
VQRSVERFKA
3D structure
PDB4z73 Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis.
ChainL
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 POP L K16 R30 Y42 K127 K17 R31 Y43 K128
BS02 MN L K127 D128 E130 K133 K128 D129 E131 K134
BS03 MN L Y42 D57 Y43 D58
BS04 MN L D57 D89 D58 D90
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006796 phosphate-containing compound metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0044228 host cell surface

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Cellular Component
External links
PDB RCSB:4z73, PDBe:4z73, PDBj:4z73
PDBsum4z73
PubMed26296329
UniProtP9WI55|IPYR_MYCTU Inorganic pyrophosphatase (Gene Name=ppa)

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