Structure of PDB 4uqv Chain L

Receptor sequence
>4uqvL (length=420) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
EYSDVPKFIRDVSIKQHEWMRESIKLIASENITSLAVREACATDFMHRYA
EGLPGKRLYQGCKYIDEVETLCIELSKELFKAEHANVQPTSGVVANLAVF
FAETKPGDKLMALSVPDGGHISHWKVAAGIRGLKVINHPFDPEEMNIDAD
AMVKKILKPKLILFGGSLFPFPHPVADAYEAAQEVGAKIAYDGAHVLGLI
AGKQFQDPLREGAEYLMGSTHKTFFGPQGGVILTTKENADKIDSHVFPGV
VHHLHHKAGLAIALAEMLEFGEAYAKQVIKNAKALAQALYERGFNVLCEH
KDFTESHQVIIDIESSPDIEFSASELAKMYEEANIILNKNLLPWDDSDNP
SGIRLGTQECTRLGMKEKEMEEIAEFMKRIAIDKEKPEKVREDVKEFAKE
YSTIHYSFDEGDGFKYLRFY
3D structure
PDB4uqv The Crystal Structure of Archaeal Serine Hydroxymethyltransferase Reveals Idiosyncratic Features Likely Required to Withstand High Temperatures.
ChainL
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y50 E52 D196 S223 K226 Q232
Catalytic site (residue number reindexed from 1) Y49 E51 D192 S219 K222 Q228
Enzyme Commision number 2.1.2.-
4.1.2.49: L-allo-threonine aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP L Y50 V255 Y49 V251
BS02 PLP L G93 V94 H121 H124 D196 A198 S223 H225 K226 G92 V93 H120 H123 D192 A194 S219 H221 K222
Gene Ontology
Molecular Function
GO:0004372 glycine hydroxymethyltransferase activity
GO:0008732 L-allo-threonine aldolase activity
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006545 glycine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0008652 amino acid biosynthetic process
GO:0019264 glycine biosynthetic process from serine
GO:0035999 tetrahydrofolate interconversion
GO:0046653 tetrahydrofolate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4uqv, PDBe:4uqv, PDBj:4uqv
PDBsum4uqv
PubMed25257552
UniProtQ58992|GLYA_METJA Serine hydroxymethyltransferase (Gene Name=glyA)

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