Structure of PDB 4kxf Chain L

Receptor sequence
>4kxfL (length=893) Species: 10090 (Mus musculus) [Search protein sequence]
YQVTEEDLNVLAQNLKDLYNSPAFLNFYPLGEDIDIIFNLEKTFTEPIMW
KKDHRHHRVEQLTLGSLLEALKSPCLIEGESGKGKSTLLQRIAMLWASGG
CRALKGFRLVFFIHLRSARGGLFETLYDQLLNIPDFISKPTFKALLLKLH
KEVLFLLDGYNEFHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHV
GALTAEVGDMTEDSAKDLIEAVLVPDQVERLWAQIQESRCLRNLMKTPLF
VVITCAIQMGRQEFQAHTQTMLFQTFYDLLIQKNSHRYRDFARSLDYCGD
LALEGVFAHKFDFEPEHGSSMNEDVLVTIGLLCKYTAQRLKPTYKFFHKS
FQEYTAGRRLSSLLTSKEPEEVSKGNSYLNKMVSISDITSLYGNLLLYTC
GSSTEATRAVMRHLAMVYQHGSLQGLSVPLWRQESIQSLRNTTEQDVLKA
INVNSFVECGINLFSESMSKSDLSQEFEAFFQGKSLYINSENIPDYLFDF
FEYLPNCASALDFVKLDFYERATPPRAVSLFFNWKQEFKTLEVTLRDINK
LNKQDIKYLGKIFSSATNLRLHIKRCAAMAGRLSSVLRTCKNMHTLMVEA
SPLTTDDEQYITSVTGLQNLSIHRLHTQQLPGGLIDSLGNLKNLERLILD
DIRMNEEDAKNLAEGLRSLKKMRLLHLTHLSDIGEGMDYIVKSLSEESCD
LQEMKLVACCLTANSVKVLAQNLHNLIKLSILDISENYLEKDGNEALQEL
IGRLGVLGELTTLMLPWCWDVHTSLPKLLKQLEGTPGLAKLGLKNWRLRD
EEIKSLGEFLEMNPLRDLQQLDLAGHCVSSDGWLYFMNVFENLKQLVFFD
FSTEEFLPDAALVRKLSQVLSKLTLLQEVKLTGWIKGTFKLVT
3D structure
PDB4kxf Crystal structure of NLRC4 reveals its autoinhibition mechanism
ChainL
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP L P119 F128 T135 S171 G172 K173 G174 K175 S176 T177 L308 P338 H443 P29 F38 T45 S81 G82 K83 G84 K85 S86 T87 L218 P248 H348
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0002218 activation of innate immune response
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0016045 detection of bacterium
GO:0032731 positive regulation of interleukin-1 beta production
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response
GO:0051260 protein homooligomerization
GO:0070269 pyroptotic inflammatory response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0061702 canonical inflammasome complex
GO:0072557 IPAF inflammasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kxf, PDBe:4kxf, PDBj:4kxf
PDBsum4kxf
PubMed23765277
UniProtQ3UP24|NLRC4_MOUSE NLR family CARD domain-containing protein 4 (Gene Name=Nlrc4)

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