Structure of PDB 3kqx Chain L

Receptor sequence
>3kqxL (length=508) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
SEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNP
GNGPVKISSKVNDKVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVG
YVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFF
LETLFYEYMTDERFKSEYIKHLGVYINNADTYKEEVEKARVYYFGTYYAS
QLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVG
KGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDL
MKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDII
TASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSL
GTSYAGVFGNNEELINKILQSSKTSNEPVWWLPIINEYRATLNSKYADIN
QISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRL
LTEFVLND
3D structure
PDB3kqx Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
ChainL
Resolution2.01 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K386 R463
Catalytic site (residue number reindexed from 1) K291 R368
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN L K374 D379 D399 E461 K279 D284 D304 E366
BS02 CO3 L A460 G462 R463 L487 A365 G367 R368 L392
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3kqx, PDBe:3kqx, PDBj:3kqx
PDBsum3kqx
PubMed20133789
UniProtQ8IL11|AMPL_PLAF7 Leucine aminopeptidase (Gene Name=LAP)

[Back to BioLiP]