Structure of PDB 2pip Chain L

Receptor sequence
>2pipL (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLV
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVD
GLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPI
ARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB2pip A surface on the androgen receptor that allosterically regulates coactivator binding.
ChainL
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT L L704 N705 M745 F764 T877 L35 N36 M76 F95 T208 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02 ICO L F673 N833 Y834 F4 N164 Y165
BS03 K10 L K720 M734 I737 Q738 I898 K51 M65 I68 Q69 I229
External links
PDB RCSB:2pip, PDBe:2pip, PDBj:2pip
PDBsum2pip
PubMed17911242
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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