Structure of PDB 2jbp Chain L

Receptor sequence
>2jbpL (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK
MLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDG
GELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT
SKRPNAILKLTDFGFAKETTYDKSCDMWSLGVIMYILLCGYPPFYSNMKT
RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ
STKVPQTPLHTSRVLKE
3D structure
PDB2jbp Structural basis for a high affinity inhibitor bound to protein kinase MK2.
ChainL
Resolution3.31 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207
Catalytic site (residue number reindexed from 1) D141 K143 E145 N146 D162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4O L L70 G73 C140 L141 D142 L193 T206 D207 L27 G30 C97 L98 D99 L148 T161 D162 BindingDB: IC50=8.5nM,EC50=49nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2jbp, PDBe:2jbp, PDBj:2jbp
PDBsum2jbp
PubMed17449059
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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