Structure of PDB 2f4v Chain L

Receptor sequence

>2f4vL (length=125) Species: 274 (Thermus thermophilus)

PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPKEAA

3D structure

• PDB: 2f4v Interactions of designer antibiotics and the bacterial ribosome aminoacyl-tRNA site
• Chain: L
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	L	P5 T6 N8 Q9 L10 R12 R15 E16 K17 K28 G29 A30 P31 F32 R33 R34 K46 K47 N49 S50 L52 R53 K54 T61 Y69 P71 G72 E73 R86 K91 D92 P94 G95 R97 V104 R113 K114 K115 S116 R117 S118 K119 Y120 G121 T122 K123 K124	P1 T2 N4 Q5 L6 R8 R11 E12 K13 K24 G25 A26 P27 F28 R29 R30 K42 K43 N45 S46 L48 R49 K50 T57 Y65 P67 G68 E69 R82 K87 D88 P90 G91 R93 V100 R109 K110 K111 S112 R113 S114 K115 Y116 G117 T118 K119 K120	PDBbind-CN: Kd=2.2uM

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:2f4v, PDBe:2f4v, PDBj:2f4v
• PDBsum: 2f4v
• PubMed: 16492561
• UniProt: Q5SHN3|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)