Structure of PDB 2c4r Chain L

Receptor sequence
>2c4rL (length=491) Species: 562 (Escherichia coli) [Search protein sequence]
AHIEGRHMKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYK
GKITRIEPSLEAAFVDYGAERHGFLPLKEIAREYFPNIKDVLREGQEVIV
QIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIELKEALASL
ELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIH
QESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKL
YTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIDINSAR
GDIEETAFNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVENR
LREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGT
VRDNESLSLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNAI
ETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTLSYMLP
3D structure
PDB2c4r Structure of E. Coli Rnase E Catalytic Domain and Implications for RNA Processing and Turnover
ChainL
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna L F57 F67 K112 G113 S121 V128 G137 G138 I139 S140 R141 I167 R169 T170 Q390 R391 F64 F74 K110 G111 S119 V126 G135 G136 I137 S138 R139 I159 R161 T162 Q378 R379
BS02 MG L D303 D346 D295 D334
BS03 ZN L C404 C407 C392 C395
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:2c4r, PDBe:2c4r, PDBj:2c4r
PDBsum2c4r
PubMed16237448
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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