Structure of PDB 2aei Chain L

Receptor sequence
>2aeiL (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQC
ASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQ
YCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
3D structure
PDB2aei The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.
ChainL
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA L E25 E29 E25 E29
BS02 CA L E7 E25 E26 E29 E7 E25 E26 E29
BS03 CA L E7 E16 E26 E29 E7 E16 E26 E29
BS04 CA L A1 N2 E6 E7 E16 E26 A1 N2 E6 E7 E16 E26
BS05 CA L A1 E6 E16 E20 A1 E6 E16 E20
BS06 CA L E19 E20 E19 E20
BS07 CA L D46 G47 Q49 D63 Q64 L65 D46 G47 Q49 D63 Q64 L65
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:2aei, PDBe:2aei, PDBj:2aei
PDBsum2aei
PubMed16125385
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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