Structure of PDB 1wss Chain L

Receptor sequence
>1wssL (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQC
ASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQ
YCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
3D structure
PDB1wss Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4.
ChainL
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC L Q49 S52 Y68 Q49 S52 Y68
BS02 FUC L S60 C72 S60 C72
BS03 CA L D46 G47 Q49 D63 Q64 D46 G47 Q49 D63 Q64
BS04 CA L E7 E26 E29 E7 E26 E29
BS05 CA L E7 E16 E26 E29 E7 E16 E26 E29
BS06 CA L A1 N2 E6 E7 E16 E26 A1 N2 E6 E7 E16 E26
BS07 CA L A1 E6 E16 E20 A1 E6 E16 E20
BS08 CA L E14 E19 E14 E19
BS09 CA L E25 E29 E25 E29
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1wss, PDBe:1wss, PDBj:1wss
PDBsum1wss
PubMed16510984
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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