Structure of PDB 1p7h Chain L

Receptor sequence
>1p7hL (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPV
VQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKI
VGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRV
RLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYG
GQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEI
PEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
3D structure
PDB1p7h Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element
ChainL
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna L Y424 T426 E427 K520 R522 N523 R537 K538 Y32 T34 E35 K128 R130 N131 R145 K146 PDBbind-CN: Kd=20nM
BS02 dna L R421 R430 R537 Q571 H575 G663 K664 R665 K666 R29 R38 R145 Q179 H183 G271 K272 R273 K274 PDBbind-CN: Kd=20nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1p7h, PDBe:1p7h, PDBj:1p7h
PDBsum1p7h
PubMed12949493
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

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