Structure of PDB 1cwd Chain L

Receptor sequence
>1cwdL (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
GSWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ
GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSR
3D structure
PDB1cwd The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
ChainL
Resolution2.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide L R12 R32 S42 K57 H58 Y59 R74 G93 R10 R30 S40 K55 H56 Y57 R72 G91
External links
PDB RCSB:1cwd, PDBe:1cwd, PDBj:1cwd
PDBsum1cwd
PubMed7532720
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

[Back to BioLiP]