Structure of PDB 8bpo Chain K2

Receptor sequence

>8bpoK2 (length=210) Species: 9986 (Oryctolagus cuniculus)

APSRNGMILKPHFHKDWQRRVATWFNQPARKIRRRKARQARARRIAPRPA
AGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPR
RRNKSTESLQANVQRLKEYRSKLVLFPRKPSAPKKGDSSAEELKLATQLT
GPVMPIRNVFKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKE
AAEQDVEKKK

3D structure

• PDB: 8bpo Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.
• Chain: K2
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	K2	A2 S4 R5 M8 L10 K11 H13 F14 H15 K16 W18 Q19 R20 W25 Q28 P29 R31 K32 R35 R36 R39 R42 R56 V59 R60 C61 P62 T63 V64 Y66 H67 R71 R74 L78 R92 D99 P100 R101 R102 R103 K105 S106 K135 K136 R158 N159 K165 F179 R183 M184 R186 A187 N188 G193 R195 K197 R198	A1 S3 R4 M7 L9 K10 H12 F13 H14 K15 W17 Q18 R19 W24 Q27 P28 R30 K31 R34 R35 R38 R41 R55 V58 R59 C60 P61 T62 V63 Y65 H66 R70 R73 L77 R91 D98 P99 R100 R101 R102 K104 S105 K134 K135 R157 N158 K164 F178 R182 M183 R185 A186 N187 G192 R194 K196 R197
BS02	rna	K2	F26 N27 A30 R34	F25 N26 A29 R33

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8bpo, PDBe:8bpo, PDBj:8bpo
• PDBsum: 8bpo
• PubMed: 37295431
• UniProt: G1TKB3|RL13_RABIT Large ribosomal subunit protein eL13 (Gene Name=RPL13)