Structure of PDB 8ylb Chain K

Receptor sequence
>8ylbK (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
IPIVVEQAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKP
IHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTP
GMRHSLPNSRIMIHQPIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMER
DRYMSPMEAQEFGILDKVLVH
3D structure
PDB8ylb Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.
ChainK
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LZA K L79 E82 I84 Y118 W146 L15 E18 I20 Y54 W82
BS02 A1LZA K L104 S108 Y138 L40 S44 Y74
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8ylb, PDBe:8ylb, PDBj:8ylb
PDBsum8ylb
PubMed38620134
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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