Structure of PDB 8wh8 Chain K

Receptor sequence
>8wh8K (length=443) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
KSYQLKGVKWLISLWQNGLNGILADQMGLGKTIQTIGFLSHLKGNGLDGP
YLVIAPLSTLSNWFNEIARFTPSINAIIYHGDKNQRDELRRKHMPKTVGP
KFPIVITSYEVAMNDAKRILRHYPWKYVVIDEGHRLKNHKCKLLRELKHL
KMDNKLLLTGTPLQNNLSELWSLLNFILPDIQVVSKLHGILRPFILRRMK
CDVELSLPRKKEIIMYATMTDHQKKFQEHLVNNTLEAHLGENAIRGQGWK
GKLNNLVIQLRKNCNHPDLLQGQIDGSYLYPPVEEIVGQCGKFRLLERLL
VRLFANNHKVLIFSQWTKLLDIMDYYFSEKGFEVCRIDGSVKLDERRRQI
KDFSDEKSSCSIFLLSTRAGGLGINLTAADTCILYDSDWNPQMDLQAMDR
CHRIGQTKPVHVYRLSTAQSIETRVLKRAYSKLKLEHVVIGQG
3D structure
PDB8wh8 Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation.
ChainK
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna K C343 K344 N367 N488 V490 R601 W622 N623 R661 K665 C141 K142 N165 N255 V257 R368 W389 N390 R428 K432
BS02 dna K D284 L486 N487 W549 T550 K551 G572 S599 A602 D82 L253 N254 W316 T317 K318 G339 S366 A369
BS03 ADP K K203 Y205 G232 I235 F272 V436 K1 Y3 G30 I33 F70 V203
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0009294 DNA-mediated transformation
GO:0031507 heterochromatin formation
GO:0032197 retrotransposition
GO:0032508 DNA duplex unwinding
GO:0040029 epigenetic regulation of gene expression
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wh8, PDBe:8wh8, PDBj:8wh8
PDBsum8wh8
PubMed38413824
UniProtQ9XFH4|DDM1_ARATH ATP-dependent DNA helicase DDM1 (Gene Name=DDM1)

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