Structure of PDB 8w1o Chain K

Receptor sequence
>8w1oK (length=1290) Species: 10905 (Bluetongue virus (serotype 1 / isolate South Africa)) [Search protein sequence]
VAITVQGAQLIKRVVERFYPGIAFNINEGACYIYKFSDHIRRIRMKHGTK
YRRQAEEIIRNISLRKERLYGIPVLDEVEWKYVFDGQTFQSYAFEVYVNS
ILPWSELDPEEEFLRNYRVSREMTEVEKFIEFRAKNEMQIYGDIPIKVWC
CFINELSAELKHVPLGMQVMADFVNRFDSPFHQGNRDLSNLEDFQVAYTT
PLLFEMCCMESILEFNIKMRMREEEISALEFGDMKVDPVGLLREFFILCL
PHPKKINNVLRAPYSWFVKMWGVGADPIVVLQSTAGDDRNSKDVFYDKFR
TEPNRYKALFRSSFYNESRRMNEEKILEAVKYSQKLGSHDRRLPLFEKML
KTVYTTPFYPHKSSNMILASFLLSIQTITGYGRAWVKNVSTEFDKQLKPN
PSNLVQDVSDLTREFFKQAYVEAKERREEIVKPEDLYTSMLRLTSSGFST
EIYVKKRFLIKINSRIKALVIFTKGHTVFTDEELHKKYNSVELYQTKGSR
DVPIKATRTIYSINLSVLVPQLIVTLPLNEYFSRVGGITSPDYKKIGGKV
IVGDLEATGSRVMDAADCFRNSADRDIFTIAIDYSEYDTHLTRHNFRTGM
LQGIREAMAPYRDLRYEGYTLEQIIDFGYGEGRVANTLWNGKRRLFKTTF
DAYIRLDESERDKGSFKVPKGVLPVSSVDVANRIAVDKGFDTLIAATDGS
DLALIDTHLSGENSTLIANSMHNMAIGTLMQREVGREQPGVLTFLSEQYV
GDDTLFYTKLHTTDTKVFDKVAASIFDTVAKCGHEASPSKTMMTPYSVEK
TQTHAKQGCYVPQDRMMIISSERRKDIEDVQGYVRSQVQTMITKVSRGFC
HDLAQLILMLKTTFIGAWKMKRTIKEDAMYRDRKFDSNDEDGFTLIQIRN
PLALYVPIGWNGYGAHPAALNIVMTEEMYVDSIMISKLDEIMAPIRRIVH
DIPPCWNETQGDKRGLISATKMSFFSKMARPAVQAALSDPQIINLVEELP
LGEFSPGRISRTMMHSALLKESSARTLLSSGYELEYQKALNSWITQVSMR
LGEESGVISTSYAKLFDVYFEGELDGAPHMFPDQNLSPQFYIQKMMIGPR
VSSRVRNSYVDRIDVILRKDVVMRGFITANTILNVIEKLGTNHSVGDLVT
VFTLMNIETRVAEELAEYMTSEKIRFDALKLLKKGIAGDEFTMSLNVATQ
DFIDTYLAYPYQLTKTEVDAISLYCTQMIMLRAALGLPKKKMKIVVTDDA
KKRYKIRLQRFRTHVPKIKVLKKLIDPNRMTVRNLENQFV
3D structure
PDB8w1o RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells.
ChainK
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna K R520 E568 R573 Q814 M828 K1032 R1037 R508 E556 R561 Q802 M816 K1020 R1025
BS02 rna K T448 R512 I522 E568 T444 R500 I510 E556
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8w1o, PDBe:8w1o, PDBj:8w1o
PDBsum8w1o
PubMed38614100
UniProtW0G557

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