Structure of PDB 8uib Chain K

Receptor sequence

>8uibK (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]

EIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYIT
RLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLE
DYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYA
GHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITEST
YATTRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMN
LKVPIYFSTGLTEKANHYYKLFIPWTNQKIRFKHIKAFDRAFADNPGPMV
VFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKL
EMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
EFLKQKIEQELRVNCYMPANGETVTL

3D structure

PDB

8uib Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.

Chain

Resolution

3.21 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	K	H68 H70 H157 D178	H63 H65 H152 D173
BS02	ZN	K	D72 H73 H414	D67 H68 H394

External links

PDB	RCSB:8uib, PDBe:8uib, PDBj:8uib
PDBsum	8uib
PubMed	39032490
UniProt	Q5TA45\|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

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