Structure of PDB 8t9f Chain K

Receptor sequence
>8t9fK (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
MSAKELCENDDLATSLVLDPYLGFQTHKMNTRQEELKEVIERFKKDEHLE
KAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCN
RYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFS
VMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGE
EISCYYGDGFFGENNEFCECYTCERRGTGAFKSINSKYGLRETDKRLNRL
KKLGDSSKNSDSQS
3D structure
PDB8t9f Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
ChainK
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM K H98 Y203 F250 A269 F270 N272 H273 Y307 F312 E320 H27 Y102 F149 A168 F169 N171 H172 Y206 F211 E219
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8t9f, PDBe:8t9f, PDBj:8t9f
PDBsum8t9f
PubMed37595555
UniProtQ4FZB7|KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (Gene Name=KMT5B)

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