Structure of PDB 8s4g Chain K

Receptor sequence

>8s4gK (length=531) [Search protein sequence]

MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLT
AQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPDW
EMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLT
SHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIP
ESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVH
IGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARR
YLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPM
LYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTA
EKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQA
LVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGH
CIEMYIGCYDFDVHTMKTLKNIISPPWDFRE

3D structure

PDB

8s4g New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C-CDH1-EMI1 complex

Chain

Resolution

Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	K	Y242 Y243 F247 V270 V276 E277 A339 H342 Y373 L376 H406 F413 K443 W444 E445 P446 N449 N450 H453 R456 K457 N478 A484 Y487 S490 L491 F514 M518 H521 E524 M525	Y221 Y222 F226 V249 V255 E256 A318 H321 Y352 L355 H385 F392 K422 W423 E424 P425 N428 N429 H432 R435 K436 N457 A463 Y466 S469 L470 F493 M497 H500 E503 M504

External links

PDB	RCSB:8s4g, PDBe:8s4g, PDBj:8s4g
PDBsum	8s4g
PubMed

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