Structure of PDB 8jhg Chain K

Receptor sequence
>8jhgK (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
SSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTQEELKEVIERFKKDEH
LEKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILP
CNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGEND
FSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEP
GEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSPAPVINSKYGLRETD
KRLNRL
3D structure
PDB8jhg Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase
ChainK
Resolution3.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM K Y203 D249 F250 I271 N272 F311 F312 E320 Y104 D150 F151 I172 N173 F212 F213 E221
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8jhg, PDBe:8jhg, PDBj:8jhg
PDBsum8jhg
PubMed38052811
UniProtQ4FZB7|KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (Gene Name=KMT5B)

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