Structure of PDB 8i0p Chain K

Receptor sequence
>8i0pK (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLL
ASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIH
MNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELE
KKKKQDLDDEEKTAKFIEEQVRRGLEGSALDEIMEIEEEKKRTARTDYWL
QPEIIVKIITKKLGEKYHKKKAIVKEVIDKYTAVVKMIDSGDKLKLDQTH
LETVIPAPGKRILVLNGGYRGNEGTLESINEKTFSATIVIETGPLKGRRV
EGIQYEDISKLA
3D structure
PDB8i0p Molecular Basis for the activation of Human spliceosome
ChainK
Resolution3.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna K R15 K19 K23 E38 R102 R9 K13 K17 E32 R96
BS02 rna K L21 Q22 K23 N92 Y95 N96 T114 L15 Q16 K17 N86 Y89 N90 T108
BS03 ZN K C28 C31 H44 H50 C22 C25 H38 H44
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006397 mRNA processing
GO:0006974 DNA damage response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0032991 protein-containing complex
GO:0043231 intracellular membrane-bounded organelle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i0p, PDBe:8i0p, PDBj:8i0p
PDBsum8i0p
PubMed39068178
UniProtO60870|KIN17_HUMAN DNA/RNA-binding protein KIN17 (Gene Name=KIN)

[Back to BioLiP]