Structure of PDB 8ham Chain K

Receptor sequence
>8hamK (length=517) Species: 9606 (Homo sapiens) [Search protein sequence]
PEELRQALMPTLEALYRQDPESLPFRQPVDPIPDYFDIVKNPMDLSTIKR
KLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEID
PVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKC
FTEISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVC
DNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVF
VRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVC
FFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYL
EYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLD
KAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKDLSQ
KLYATMEKHKEVFFVIHLHDPDPLLSCDLMDGRDAFLTLARDKHWEFSSL
RRSKWSTLCMLVELHTQ
3D structure
PDB8ham Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
ChainK
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna K R1173 K1176 K1492 K1495 R1498 E1528 D1529 R83 K86 K384 K387 R390 E420 D421
BS02 dna K R1169 T1171 R1173 R1443 K1505 F1523 K1524 R79 T81 R83 R335 K397 F415 K416
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ham, PDBe:8ham, PDBj:8ham
PDBsum8ham
PubMed37460559
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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