Structure of PDB 8haj Chain K

Receptor sequence
>8hajK (length=533) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDL
STIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVF
EQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYH
FCEKCFNEIQGESNKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHE
IIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQ
NHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAF
EEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAV
YHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRL
QEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVL
EESIKENDLSQKLYATMEKHKEVFFVIRLIIVDPDPLIPCDLMDGRDAFL
TLARDKHLEFSSLRRAQWSTMCMLVELHTQSQD
3D structure
PDB8haj Epigenetic mechanisms to propagate histone acetylation by p300/CBP.
ChainK
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna K K1134 K1140 K1488 T1491 E1492 D1493 R1494 K85 K91 K425 T428 E429 D430 R431
BS02 dna K R1133 R1137 F1487 E1589 K1592 R84 R88 F424 E468 K471
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8haj, PDBe:8haj, PDBj:8haj
PDBsum8haj
PubMed37460559
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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