Structure of PDB 8h7g Chain K

Receptor sequence
>8h7gK (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
PRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRK
LTVEDFNRALRWSSVEAVCGYGSQEALPMRPYFPEDREVNLVELALATNI
PKGCAETAVRVHVSYLSVPSAVSSLTDDLLKYYHQVTRAVLGDDPQLMKV
ALQDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPH
LCLGPYVRCLVGSVLYCVLEHWTLRDGAALLLSHIFWTHGDLVSGLYQHI
LLSLQKILADPVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQA
VLDDYSVSNAQVKADGHKVYGAILVAVERLLLLFQESSSGGGAEPSFGSG
LP
3D structure
PDB8h7g Cryo-EM structure of human SAGA transcriptional coactivator complex.
ChainK
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide K W276 Q287 W319 K320 A321 R324 W237 Q248 W280 K281 A282 R285
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006282 regulation of DNA repair
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0043484 regulation of RNA splicing
GO:0045893 positive regulation of DNA-templated transcription
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:1904672 regulation of somatic stem cell population maintenance
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000124 SAGA complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0046695 SLIK (SAGA-like) complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h7g, PDBe:8h7g, PDBj:8h7g
PDBsum8h7g
PubMed36414614
UniProtQ9Y6J9|TAF6L_HUMAN TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (Gene Name=TAF6L)

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