Structure of PDB 8fd7 Chain K

Receptor sequence

>8fd7K (length=1270) Species: 9606 (Homo sapiens)

PIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLER
VEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAI
KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA
IIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK
PGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWI
YFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEED
LKGYLDWITQAEDIDPRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASE
HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCF
VVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL
LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQ
SLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYIL
LNVFLAIAVDNLADAESLTSFRLQCHRIVNDTIFTNLILFFILLSSISLA
AEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNY
FNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHV
VQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAE
CKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWP
ELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVT
FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNS
TYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMIL
KLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITSITFFRLFRVMRLVKLL
SRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT
TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNS
TEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILG
PHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVAC
KRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIK
KIWKRTSMKLLDQVVPPAGD

3D structure

• PDB: 8fd7 Structural basis for Ca V alpha 2 delta :gabapentin binding.
• Chain: K
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	WO9	K	F357 V396 N741 F1114	F224 V263 N547 F796
BS02	YSW	K	F239 Y719 P725	F106 Y525 P531
BS03	CLR	K	H545 N1100 L1102	H351 N782 L784
BS04	CLR	K	N348 A1237 M1238 H1240	N215 A919 M920 H922
BS05	CA	K	E363 E706 E1115	E230 E512 E797

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane

External links

• PDB: RCSB:8fd7, PDBe:8fd7, PDBj:8fd7
• PDBsum: 8fd7
• PubMed: 36973510
• UniProt: Q13936|CAC1C_HUMAN Voltage-dependent L-type calcium channel subunit alpha-1C (Gene Name=CACNA1C)