Structure of PDB 8br4 Chain K

Receptor sequence

>8br4K (length=339) Species: 1773 (Mycobacterium tuberculosis)

MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNSTLAHLL
KFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVV
VESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQ
NIISNASCTTNCLAPLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKD
LRRARAAALNIVPTSTGAAKAIGLVMPQLKGKLDGYALRVPIPTGSVTDL
TVDLSTRASVDEINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIF
DSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL

3D structure

• PDB: 8br4 Structure of GAPDH from Mycobacterium tuberculosis
• Chain: K
• Resolution: 3.29 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.12: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	K	G9 G11 R12 I13 N38 D39 S103 T104 G105 S127 C158 T188 Q189 N320	G9 G11 R12 I13 N38 D39 S103 T104 G105 S127 C158 T188 Q189 N320

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005576 extracellular region
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0009274 peptidoglycan-based cell wall

External links

• PDB: RCSB:8br4, PDBe:8br4, PDBj:8br4
• PDBsum: 8br4
• UniProt: P9WN83|G3P_MYCTU Glyceraldehyde-3-phosphate dehydrogenase (Gene Name=gap)