Structure of PDB 8aox Chain K

Receptor sequence
>8aoxK (length=432) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
PVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDHANARAFSHLAIKLIE
QEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLAS
AAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQD
VYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWADE
QVLKAKNIGLCSTDLTEGRRGKLSIMRGKKLEPCDRVLFSVGSTLYPESR
KLLKSWHLPSVFHLKGKLSTCRCDTVVSCEGYVVKRITMSPGLYGKTTGY
AVTHHADGFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVTPE
DAQKLLVGLNQNTMKNYMIPVVAQAFSKWAKECRKDMEDEKLLGVRERTL
TCCCLWAFKKQKTHTVYKRPDTQSIQKVQAEF
3D structure
PDB8aox Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores.
ChainK
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN K H79 E129 C134 C141 H77 E127 C132 C139
BS02 SAM K G65 A67 P83 S86 D89 R92 T137 D138 Q151 D152 G63 A65 P81 S84 D87 R90 T135 D136 Q149 D150
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008174 mRNA methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0016556 mRNA modification

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Molecular Function
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Biological Process
External links
PDB RCSB:8aox, PDBe:8aox, PDBj:8aox
PDBsum8aox
PubMed36913573
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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