Structure of PDB 7z6h Chain K

Receptor sequence
>7z6hK (length=439) Species: 9606 (Homo sapiens) [Search protein sequence]
ENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQGGSILLIT
GPPGCGKTTTLKILSKEHGIQVQEWINPVLPYQSQIAVFKEFLLRATKYN
KLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPLIFI
ISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTIEA
NKNGGKITVPDKTSLELLCQGCSGDIRSAINSLQFSSSKAIGGKDVSLFL
FRALGKILYCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPG
DLFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGDWNTRSLLREYSTS
IATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKAL
FPDLCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLPLK
3D structure
PDB7z6h Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction.
ChainK
Resolution3.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0140463 chromatin-protein adaptor activity
Biological Process
GO:0000076 DNA replication checkpoint signaling
GO:0000077 DNA damage checkpoint signaling
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006974 DNA damage response
GO:0008156 negative regulation of DNA replication
GO:0021762 substantia nigra development
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0042325 regulation of phosphorylation
GO:0051598 meiotic recombination checkpoint signaling
GO:0071479 cellular response to ionizing radiation
GO:1990166 protein localization to site of double-strand break
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0030896 checkpoint clamp complex
GO:0031389 Rad17 RFC-like complex
GO:0035861 site of double-strand break
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z6h, PDBe:7z6h, PDBj:7z6h
PDBsum7z6h
PubMed35819203
UniProtO60671|RAD1_HUMAN Cell cycle checkpoint protein RAD1 (Gene Name=RAD1);
O75943

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