Structure of PDB 7yrd Chain K

Receptor sequence
>7yrdK (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
GQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTRQEELKEVI
ERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFAT
DSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENM
LLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACV
KALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSKYGLRET
DKRLNRLKK
3D structure
PDB7yrd Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1.
ChainK
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna K G62 R286 G1 R195
BS02 ZN K C275 C321 C324 C184 C230 C233
BS03 SAM K H98 Y203 G209 A210 F250 A269 H273 Y307 F312 F318 E320 H37 Y112 G118 A119 F159 A178 H182 Y216 F221 F227 E229
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7yrd, PDBe:7yrd, PDBj:7yrd
PDBsum7yrd
PubMed37536340
UniProtQ4FZB7|KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (Gene Name=KMT5B)

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