Structure of PDB 7ycx Chain K

Receptor sequence
>7ycxK (length=590) Species: 9606 (Homo sapiens) [Search protein sequence]
EIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYIT
QNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPI
LLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKA
YYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLIT
ESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILL
ETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMFEF
KHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPG
YCVQGTVGHKILSGQRKLEVLEVKMQVEYMSFSAHADAKGIMQLVGQAEP
ESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGIS
LGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEH
QLRFTCRVHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVL
LQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQ
3D structure
PDB7ycx Structural basis of INTAC-regulated transcription.
ChainK
Resolution4.18 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna K M37 H70 L71 D106 Y107 I110 H157 F240 R310 T324 P325 H329 A330 Q332 Y353 H392 M35 H68 L69 D104 Y105 I108 H155 F238 R308 T322 P323 H327 A328 Q330 Y351 H385
BS02 ZN K D72 H73 D178 H414 D70 H71 D176 H407
BS03 ZN K H68 H70 H73 H157 D178 H66 H68 H71 H155 D176
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex
GO:0072562 blood microparticle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ycx, PDBe:7ycx, PDBj:7ycx
PDBsum7ycx
PubMed36869814
UniProtQ5TA45|INT11_HUMAN Integrator complex subunit 11 (Gene Name=INTS11)

[Back to BioLiP]