Structure of PDB 7xfh Chain K

Receptor sequence
>7xfhK (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
HLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLGPE
DEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLL
RALEPLEGLETMRQLRSTVLKDRELCSGPSKLCQALAINKSFDQRDLAQD
EAVWLERGPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQD
3D structure
PDB7xfh Structure of nucleosome-AAG complex (A-30I, post-catalytic state)
ChainK
Resolution2.9 Å
3D
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Enzymatic activity
Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna K I161 Y162 Y165 R197 G217 P218 S219 K220 I80 Y81 Y84 R116 G128 P129 S130 K131
BS02 dna K T143 R145 Y162 G163 T62 R64 Y81 G82
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
GO:0005515 protein binding
GO:0008725 DNA-3-methyladenine glycosylase activity
GO:0016787 hydrolase activity
GO:0019104 DNA N-glycosylase activity
GO:0043916 DNA-7-methylguanine glycosylase activity
GO:0052821 DNA-7-methyladenine glycosylase activity
GO:0052822 DNA-3-methylguanine glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006307 DNA alkylation repair
GO:0045007 depurination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0042645 mitochondrial nucleoid

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Cellular Component
External links
PDB RCSB:7xfh, PDBe:7xfh, PDBj:7xfh
PDBsum7xfh
PubMed37339965
UniProtP29372|3MG_HUMAN DNA-3-methyladenine glycosylase (Gene Name=MPG)

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