Structure of PDB 7x01 Chain K

Receptor sequence
>7x01K (length=421) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]
DPVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDHANARAFSHLAIKLI
EQEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLA
SAAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQ
DVYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWAD
EQVLKAKNIGLCSTDLTEGRRGRGKKLEPCDRVLFSVGSTLYPESRKLLK
SWHLPSVFHLKGKLSFTCRCDTVVSCEGYVVKRITMSPGLYGKTTGYAVT
HHADGFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVTPEDAQ
KLLVGLNNTMKNYMIPVVAQAFSKWAKECRKDMEDEKLLGVRERAFKKQK
THTVYKRPDTQSIQKVQAEFD
3D structure
PDB7x01 Molecular basis of specific viral RNA recognition and 5'-end capping by the Chikungunya virus nsP1.
ChainK
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN K H79 E129 C134 C141 H78 E128 C133 C140
BS02 7XQ K P83 D89 D138 P82 D88 D137
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008174 mRNA methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0016556 mRNA modification

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Molecular Function
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Biological Process
External links
PDB RCSB:7x01, PDBe:7x01, PDBj:7x01
PDBsum7x01
PubMed35905713
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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