Structure of PDB 7wgs Chain K

Receptor sequence
>7wgsK (length=181) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
LIPTVYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYL
YINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKR
FALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSI
EKIQKDTDRDNFLTAEEAKEYGLIDEVMVPE
3D structure
PDB7wgs Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.
ChainK
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9A2 K R23 L24 D27 I29 Y61 Y63 Q89 I91 M190 R11 L12 D15 I17 Y49 Y51 Q77 I79 M178
BS02 9A2 K L49 F50 L37 F38
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0051117 ATPase binding
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
Cellular Component
GO:0005737 cytoplasm
GO:0009368 endopeptidase Clp complex

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External links
PDB RCSB:7wgs, PDBe:7wgs, PDBj:7wgs
PDBsum7wgs
PubMed36376309
UniProtQ2G036|CLPP_STAA8 ATP-dependent Clp protease proteolytic subunit (Gene Name=clpP)

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