Structure of PDB 7vp9 Chain K

Receptor sequence
>7vp9K (length=176) Species: 9606 (Homo sapiens) [Search protein sequence]
PLIPIVVEERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESN
KKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAA
GTPGMRHSLPNSRIMIHQPIQAEEIMKLKKQLYNIYAKHTKQSLQVIESA
MERDRYMSPMEAQEFGILDKVLVHPP
3D structure
PDB7vp9 Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma.
ChainK
Resolution2.552 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7SR K L104 F105 Q107 Y138 L43 F44 Q46 Y77
BS02 7SR K I75 R78 L79 E82 W146 I14 R17 L18 E21 W85
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7vp9, PDBe:7vp9, PDBj:7vp9
PDBsum7vp9
PubMed35905743
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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