Structure of PDB 7uv9 Chain K

Receptor sequence
>7uv9K (length=407) Species: 9606 (Homo sapiens) [Search protein sequence]
RYSQRLRRRYRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDP
LIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQ
WTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPR
HLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIH
QGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYT
FVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFR
YPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLEQVHLTHFELEG
LRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTG
VPIVQWP
3D structure
PDB7uv9 Structural basis of paralog-specific KDM2A/B nucleosome recognition.
ChainK
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OH0 K I144 Y199 L201 T209 H212 Y222 K229 H284 V286 N298 I119 Y174 L176 T184 H187 Y197 K204 H259 V261 N273
BS02 FE K H212 D214 H284 H187 D189 H259
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7uv9, PDBe:7uv9, PDBj:7uv9
PDBsum7uv9
PubMed36797403
UniProtQ9Y2K7|KDM2A_HUMAN Lysine-specific demethylase 2A (Gene Name=KDM2A)

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