BioLiP

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

D95 D97 N99 Y101 E106

BS04

D129 D131 D133 Q135 E140

D131 D133 D135 Q137 E142

	Molecular Function
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0010856	adenylate cyclase activator activity
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0031432	titin binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0044325	transmembrane transporter binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0072542	protein phosphatase activator activity

	Biological Process
GO:0000086	G2/M transition of mitotic cell cycle
GO:0002027	regulation of heart rate
GO:0005513	detection of calcium ion
GO:0007186	G protein-coupled receptor signaling pathway
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016240	autophagosome membrane docking
GO:0021762	substantia nigra development
GO:0031954	positive regulation of protein autophosphorylation
GO:0032465	regulation of cytokinesis
GO:0035458	cellular response to interferon-beta
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT
GO:0050848	regulation of calcium-mediated signaling
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592	response to calcium ion
GO:0055117	regulation of cardiac muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0071346	cellular response to type II interferon
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0098901	regulation of cardiac muscle cell action potential
GO:0140056	organelle localization by membrane tethering
GO:0140238	presynaptic endocytosis
GO:1901020	negative regulation of calcium ion transmembrane transporter activity
GO:1901842	negative regulation of high voltage-gated calcium channel activity
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1905913	negative regulation of calcium ion export across plasma membrane
GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering

Biological Process

GO:0000086

G2/M transition of mitotic cell cycle

GO:0002027

regulation of heart rate

GO:0005513

detection of calcium ion

GO:0007186

G protein-coupled receptor signaling pathway

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

GO:0010801

negative regulation of peptidyl-threonine phosphorylation

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

GO:0010881

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

GO:0016240

autophagosome membrane docking

GO:0021762

substantia nigra development

GO:0031954

positive regulation of protein autophosphorylation

GO:0032465

regulation of cytokinesis

GO:0035458

cellular response to interferon-beta

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

GO:0050848

regulation of calcium-mediated signaling

GO:0051343

positive regulation of cyclic-nucleotide phosphodiesterase activity

GO:0051592

response to calcium ion

GO:0055117

regulation of cardiac muscle contraction

GO:0060314

regulation of ryanodine-sensitive calcium-release channel activity

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

GO:0071346

cellular response to type II interferon

GO:0071902

positive regulation of protein serine/threonine kinase activity

GO:0098901

regulation of cardiac muscle cell action potential

GO:0140056

organelle localization by membrane tethering

GO:0140238

presynaptic endocytosis

GO:1901020

negative regulation of calcium ion transmembrane transporter activity

GO:1901842

negative regulation of high voltage-gated calcium channel activity

GO:1901844

regulation of cell communication by electrical coupling involved in cardiac conduction

GO:1905913

negative regulation of calcium ion export across plasma membrane

GO:1990456

mitochondrion-endoplasmic reticulum membrane tethering

	Cellular Component
GO:0000922	spindle pole
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030017	sarcomere
GO:0031514	motile cilium
GO:0031982	vesicle
GO:0032991	protein-containing complex
GO:0034704	calcium channel complex
GO:0043209	myelin sheath
GO:0044305	calyx of Held
GO:0097225	sperm midpiece
GO:0099523	presynaptic cytosol
GO:1902494	catalytic complex

Cellular Component

spindle pole

extracellular region

nucleus

nucleoplasm

cytoplasm