Structure of PDB 7syp Chain K

Receptor sequence

>7sypK (length=185) Species: 9986 (Oryctolagus cuniculus)

PVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLA
KIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLK
IEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRL
DSQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAG

3D structure

• PDB: 7syp Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
• Chain: K
• Resolution: 4.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	K	P2 R5 W7 V8 C9 R10 T12 T15 P16 R17 R18 P19 F20 R38 N39 K40 R41 R45 R69 E73 R80 S122 H124 R127 R131 Q132 R133 H134 R138 Q140 N143 I144 P145 S146 F147 R150 S153 R162 Y165 G171 R172 V173 K174 K176 N177	P1 R4 W6 V7 C8 R9 T11 T14 P15 R16 R17 P18 F19 R37 N38 K39 R40 R44 R68 E72 R79 S121 H123 R126 R130 Q131 R132 H133 R137 Q139 N142 I143 P144 S145 F146 R149 S152 R161 Y164 G170 R171 V172 K173 K175 N176

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0043226 organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7syp, PDBe:7syp, PDBj:7syp
• PDBsum: 7syp
• PubMed: 35822879
• UniProt: B7NZS8|RS9_RABIT Small ribosomal subunit protein uS4 (Gene Name=RPS9)