Structure of PDB 7sn8 Chain K

Receptor sequence
>7sn8K (length=588) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
PDIKITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFSYI
VPEGPITSHIDCVIISHFHLDHCGALPYMSEIVGYTGPIYMTHPTKAIAP
ILLEDMRKVAVERFFTTQMIKDCMKKVIPVTLHQSMMVDTDLEIKAYYAG
HVLGAAMFWIKVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDLLISESTY
ATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYW
ERMNLKYPIYFALEKANTYYKMFITWTNQKIRKTFVHRNMFDFKHIKPFD
KAYIDNPGAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTV
GNKILGGAKKVEFENRQVVEVKMAVEYMSFSAHADAKGIMQLIQNCEPKN
VMLVHGEAGKMKFLRSKIKDEFNLETYMPANGETCVISTPVKIPVDASVS
LLKAEARSYNAQPPDPKRRRLIHGVLVMKDNRIMLQNLTDALKEIGINRH
VMRFTSKVKMDDSGPVIRTSERLKTLLEEKLAGWTVTMQENGSIAIESVE
VKVEEDEKDPKQKNILISWTNQDEDIGAYILNVLQNMC
3D structure
PDB7sn8 Inositol hexakisphosphate is required for Integrator function.
ChainK
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN K H68 H70 H157 H67 H69 H151
BS02 ZN K H73 D178 H414 H72 D172 H405
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
GO:0031123 RNA 3'-end processing
GO:0034472 snRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032039 integrator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sn8, PDBe:7sn8, PDBj:7sn8
PDBsum7sn8
PubMed36180473
UniProtQ9VAH9|INT11_DROME Integrator complex subunit 11 (Gene Name=IntS11)

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